Neuraminidase inhibitors (NAIs)#

PA inhibitors

Souche

Protein

Mutation

N2 numbering*

Comments¤

Oseltamivir

FC.IC50.oseltamivir

Zanamivir

FC.IC50.zanamivir

Baloxavir

FC.IC50.Baloxavir

References

A(H1N1)pdm09

NA

S110F

110

RI

10

RI

17-18

(1, 2)

A(H1N1)pdm09

NA

I117R

117

Mutation I117T found in A(H5N1): RI to oseltamivir and zanamivir

NI

1

RI

10

(3)

A(H1N1)pdm09

NA

E119A

119

Mutation found in A(H5N1) with same resistance profile

NI/RI

8-17

RI

58-90

(4, 5)

A(H1N1)pdm09

NA

E119D

119

Mutation found in A(H5N1) with same resistance profile

RI

25-94

HRI

583-2731

(5-7)

A(H1N1)pdm09

NA

E119G

119

Mutation found in A(H5N1) with same resistance profile

NI

1-7

HRI

113-1306

(5, 7-9)

A(H1N1)pdm09

NA

E119V

119

Mutation found in A(H1N1) before 2009 linked to higher resistance at least HRI for all NAI

RI

60

HRI

571

(8)

A(H1N1)pdm09

NA

Q136K

136

Mutation found in A(H1N1) before 2009 with same resistance profile

NI

1

HRI

86-749

(4, 10, 11)

A(H1N1)pdm09

NA

Q136R

136

Mutation Q136L found in A(H5N1) : RI to oseltamivir and HRI to zanamivir

NI

1

HRI

200

(12)

A(H1N1)pdm09

NA

R152K

152

RI

18-43

NI/RI

4-12

(5, 7)

A(H1N1)pdm09

NA

D199E

198

RI

16-26

NI

7-8

(7, 13)

A(H1N1)pdm09

NA

D199G

198

Mutation found in A(H5N1) with same resistance profile

RI

17

NI

6

(4, 8)

A(H1N1)pdm09

NA

D199Y

198

RI

37

RI

28

(14)

A(H1N1)pdm09

NA

I223K

222

RI

12–39

NI

5–6

(13, 15, 16)

A(H1N1)pdm09

NA

I223L

222

RI

11

NI

2

(17)

A(H1N1)pdm09

NA

I223R

222

RI

13–45

NI/RI

8–12

(13, 16, 18-20)

A(H1N1)pdm09

NA

I223T

222

NI/RI

9-15

NI

3

(4)

A(H1N1)pdm09

NA

S247G

246

RI

15

NI

1

(13)

A(H1N1)pdm09

NA

S247R

246

RI

36-37

RI

51-54

(3)

A(H1N1)pdm09

NA

H275Y

274

Main mutation found in all N1 and linked with HRI to oseltamivir and peramivir. This mutation could be linked to other mutation like substitution on 119 to become RI/HRI to all NAI

HRI

221–1637

NI

1–6

(22-31)

A(H1N1)pdm09

NA

R293K

292

RI

33

NI

4

(5, 9)

A(H1N1)pdm09

NA

N295S

294

Mutation found in A(H1N1) before 2009 and A(H5N1) with same resistance profile

RI/HRI

64-208

NI

2-9

(4, 5, 8, 12)

A(H1N1)pdm09

NA

I427T

427

RI

37

RI

41

(14)

A(H1N1)pdm09

NA

I436N

436

RI

31

RI

71

(32)

A(H1N1)pdm09

NA

P458T

459

HRI

280

HRI

808

(7)

A(H1N1)pdm09

PA

E23G

*

4−7

(7-10)

A(H1N1)pdm09

PA

E23K

Mutation found in A(H1N1) before 2009 with same resistance profile

*

7−13

(9-11)

A(H1N1)pdm09

PA

E23R

*

13

(12)

A(H1N1)pdm09

PA

K34R

*

2−5

(9)

A(H1N1)pdm09

PA

A37T

*

5

(13)

A(H1N1)pdm09

PA

I38F

Mutation found in A(H1N1) before 2009 with same resistance profile

*

7−17

(14, 15)

A(H1N1)pdm09

PA

I38L

Mutation found in A(H1N1) before 2009 with same resistance profile

*

7−12

(7, 8, 16, 17)

A(H1N1)pdm09

PA

I38M

Mutation found in A(H1N1) before 2009 with same resistance profile

*

7− 9

(14, 15, 18)

A(H1N1)pdm09

PA

I38S

Mutation found in A(H1N1) before 2009 with same resistance profile

R

31−112

(9, 11, 16, 19)

A(H1N1)pdm09

PA

I38T

Mutation found in A(H1N1) before 2009 with same resistance profile

R

11−124

(9, 11, 14-16, 20,21)

A(H1N1)pdm09

PA

I38V

Mutation found in A(H1N1) before 2009 with same resistance profile

*

2−4

(7, 9)

A(H1N1)pdm09

PA

E198K

Mutation found in A(H1N1) before 2009 with same resistance profile

*

2

(6)

A(H1N1)pdm09

PA

E199D

*

3

(17)

A(H1N1)pdm09

PA

E199G

*

1−4

(9, 18)